Perkuliahan ini berisi tentang Respon mikroorganisme terhadap kondisi lingkungan: pengaturan ekspresi gen tertentu, koordinasi antar sel mikroorganisme untuk ekspresi gen. 

Bacterial Signal Transduction (Two component system): Physiological Functions of Two-component systems : 

–nutrient acquisition : nitrogen, phosphorus, carbon
–energy metabolism : electron transport systems, uptake and catabolic machinery
–adaptation to physical or chemical aspects of the environment : chemotaxis, pH, osmolarity, light quality
–complex developmental pathways : sporulation, fruiting body development, swarmer cell production
–virulence : plasmid transfer (conjugation), degredative secretions, toxin production
Quorum sensing